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Standard Test Method for Determination of Nitrosamines in Water by Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)Translate name
STANDARD published on 1.5.2022
Designation standards: ASTM D8456-22
Publication date standards: 1.5.2022
The number of pages: 8
Approximate weight : 24 g (0.05 lbs)
Country: American technical standard
Category: Technical standards ASTM
environmental, LC-MS/MS, liquid chromatography, mass spectrometry, nitrosamines, non-potable water, organic, wastewater, water reuse,
|Significance and Use|
5.1Nitrosamines are a class of nitrogen-containing compounds with a known occurrence in wastewater. They may also be created in deionization and are a potential contaminant in water for reuse. The World Health Organization has issued a guideline for NDMA in drinking water at 0.1 g/L. NDMA may occur in chlorinated effluents and other wastewaters. Other methods for nitrosamines employ solid phase extraction, which may not be applicable to wastewaters that contain particulate matter or a high organic load. This method analyses nitrosamines directly using LC-MS/MS.
1.1This test method covers the liquid chromatography tandem mass spectrometry (LC-MS/MS) detection and quantitation of N-nitrosamines after direct injection. It has been validated for groundwater, surface water, wastewater influents, and wastewater effluents. This test method is not limited to these aqueous matrices; however, the applicability of this test method to other aqueous matrices must be demonstrated.
1.2This test method is applicable to nitrosamines that can be chromatographed and detected using a mass spectrometry procedure. lists the compounds that have been validated for this test method. This test method is not limited to the compounds listed in ; however, the applicability of the test method to other compounds must be demonstrated.
1.3Analyte concentrations from 0.05 g/L up to approximately 5 g/L may be determined without dilution of the sample. Analytes with insufficient sensitivity will not be detected, but they can be measured with acceptable accuracy and precision when present in sufficient amounts. In addition, newer instruments, or instruments of improved sensitivity may be used to lower detection limits.
1.4Analytes that are not separated chromatographically, but that have different mass spectra and noninterfering quantitation ions, can be identified and measured in the same calibration mixture or water sample. Analytes that have very similar product ions cannot be individually identified and measured in the same calibration mixture or water sample unless they have different retention times.
1.5It is the responsibility of the user to ensure the validity of this test method for untested matrices.
1.6This test method is restricted to use by or under the supervision of analysts experienced in the use of a liquid chromatograph with tandem mass spectrometry (LC-MS/MS).
1.7Depending on data usage, you may modify this test method but limit to modifications that improve performance while still meeting method quality acceptance criteria. Shortening the chromatographic run simply to save time is not allowed. Use Practice or similar statistical tests to confirm that modifications produce equivalent results on non-interfering samples. In addition, use Guide or equivalent statistics to re-validate the modified test.
1.8The values stated in SI units are to be regarded as standard. No other units of measurement are included in this standard.
1.9This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish appropriate safety, health, and environmental practices and determine the applicability of regulatory limitations prior to use.
1.10This international standard was developed in accordance with internationally recognized principles on standardization established in the Decision on Principles for the Development of International Standards, Guides and Recommendations issued by the World Trade Organization Technical Barriers to Trade (TBT) Committee.
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Latest update: 2022-11-27 (Number of items: 2 642 910)
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